書誌事項
- タイトル別名
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- The New Era of Epithelium-targeted Drug Development
- Symposium Review 上皮を標的とした創薬研究のらせん的発展
- Symposium Review ジョウヒ オ ヒョウテキ ト シタ ソウヤク ケンキュウ ノ ラセン テキ ハッテン
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説明
Epithelium plays pivotal roles in biological barrier separating the inside of body and the outside environment. Ninety percent of malignant tumors are derived from epithelium. Most pathological microorganisms invade into the body from mucosal epithelium. Thus, epithelium is potential targets for drug development. Claudins (CLs), a family of tetra-transmembrane protein consisting of over 20 members, are structural and functional components of tight junction-seals in epithelium. Modulation of CL-seals enhanced mucosal absorption of drugs. CLs are often over-expressed in malignant tumors. CL-4 expression is increased in the epithelial cells covering the mucosal immune tissues. Very recently, CLs are also expected to be targets for traumatic brain injury and regenerative therapy. In this review, we overview the past, the present and the future of CLs-targeted drug development.<br>
収録刊行物
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- 薬学雑誌
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薬学雑誌 134 (5), 641-645, 2014-05-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282681105592960
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- NII論文ID
- 130004756437
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- NII書誌ID
- AN00284903
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- COI
- 1:STN:280:DC%2BC2cnpsVCruw%3D%3D
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 025499978
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- PubMed
- 24790047
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可