-
- 伊藤 久央
- <i>東京薬科大学生命科学部</i>
書誌事項
- タイトル別名
-
- Development of Novel Carbon-Carbon Bond Forming Reactions Using Zirconocene Complex
- ジルコノセン サクタイ オ モチイタ シンキ タンソ タンソ ケツゴウ ケイセイ ハンノウ ノ カイハツ
この論文をさがす
説明
Novel zirconium-mediated carbon-carbon bond-forming reactions were developed. The allylic, γ-alkoxyallylic, allenyl, and γ,γ-dialkoxyallylic zirconium species can be prepared from corresponding ethers under mild conditions through the addition of a zirconocene-butene complex to the carbon-carbon multiple bond of the ethers and subsequent β-elimination of the alkoxyl group. The γ,γ-dialkoxyallylic zirconium species reacts with carbonyl compounds at the β-position of the zirconium atom like a ketene dialkyl acetal in the presence of stoichiometric amounts of Lewis acid and gave cyclopropane and/or cyclobutane derivatives. Intramolecular reaction of allylic zirconium species with acetal also develops as a ring contraction reaction of carbohydrates and morpholine derivatives. This method is useful for the construction of chiral highly functionalized carbocycles and pyrrolidines. The intramolecular ester transfer reaction through the zirconium-mediated coupling reaction of alkenyl carbamates gave γ-aminobutyric acid derivatives and pyrrolidine-3-carboxylic acids.<br>
収録刊行物
-
- 薬学雑誌
-
薬学雑誌 123 (11), 933-948, 2003-11-01
公益社団法人 日本薬学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282681105630976
-
- NII論文ID
- 110003614857
-
- NII書誌ID
- AN00284903
-
- ISSN
- 13475231
- 00316903
-
- NDL書誌ID
- 6745444
-
- PubMed
- 14631755
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可