Pharmaceutical Applications of Cyclodextrin Complexations

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Other Title
  • シクロデキストリンComplexの製剤への応用
  • シクロデキストリン Complex ノ セイザイ エ ノ オウヨウ
  • Pharmaaceutical application of cyclodextrin complexations

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Abstract

Cyclodextrins are homologous series of cyclic oligosaccharides consisting of glucose units joined by α-1, 4 linkages. One of the important characteristics of cyclodextrins is the formation of inclusion complexes with various guest molecules in solid phase and in solution, in which the guest molecules are included in the relatively hydrophobic cavity of cyclodextrins. The present review is mainly concerned with the possible utilities of cyclodextrins in pharmaceutical fields. A number of examples such as improvements of solubility, chemical stability, bioavailability, etc. are presented. These informations will provide a rational basis for design of formulation and a means for improving efficacy of drug activity.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 101 (10), 857-873, 1981

    The Pharmaceutical Society of Japan

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