Biopharmaceutical Studies of Drugs. V. Dissolution Properties and Bioavailability of Ground Mixtures of Poorly Water Soluble Drugs and Soluble Proteins

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  • 医薬品の生物薬剤学的研究(第5報)難溶性薬物と可溶性蛋白質との混合粉砕物の溶解性とBioavailability
  • 医薬品の生物薬剤学的研究-5-難溶性薬物と可溶性蛋白質との混合粉砕物の溶解性とBioavailability
  • イヤクヒン ノ セイブツ ヤクザイガクテキ ケンキュウ 5 ナンヨウセイ ヤク

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Abstract

The ground mixtures of several poorly water soluble drugs such as diphenylhydantoin (DPH) and soluble proteins such as gelatin, were prepared in order to improve dissolution properties and gastrointestinal absorption of the drugs. The drugs in the ground mixtures were found to be an amorphous form by the differential scanning calorimetry (DSC) and the X-ray diffraction measurement. The dissolution rates of the ground mixtures of poorly water soluble drugs and soluble proteins increased more markedly than the drugs alone and were greater than those of the ground mixtures of the drugs and microcrystalline cellulose (MCC). The ground mixture of DPH and gelatin (A), DPH alone (B) and the ground mixture of DPH and MCC (C) were administered in the dogs, and the DPH concentration in the serum were measured. As the result, the area under the serum concentration-time curve of A was 5.3, 1.7 times greater than those of B and C, respectively.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 101 (8), 733-739, 1981

    The Pharmaceutical Society of Japan

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