Liposome Modified with VIP-Lipopeptide as a New Drug Delivery System
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- Masaka Toru
- School of Pharmaceutical Sciences, Toho University Sakura Medical Center, Toho University
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- Li Yingpeng
- School of Pharmaceutical Sciences, Toho University
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- Kawatobi Sho
- School of Pharmaceutical Sciences, Toho University
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- Koide Yuki
- School of Pharmaceutical Sciences, Toho University
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- Takami Akira
- School of Pharmaceutical Sciences, Toho University
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- Yano Kenji
- School of Pharmaceutical Sciences, Toho University
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- Imai Ryosuke
- School of Pharmaceutical Sciences, Toho University
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- Yagi Nobuhiro
- School of Pharmaceutical Sciences, Toho University
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- Suzuki Hideharu
- School of Pharmaceutical Sciences, Toho University
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- Hikawa Hidemasa
- School of Pharmaceutical Sciences, Toho University
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- Tatsuno Ichirou
- Sakura Medical Center, Toho University
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- Terada Katsuhide
- School of Pharmaceutical Sciences, Toho University
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- Yokoyama Yusaku
- School of Pharmaceutical Sciences, Toho University
Bibliographic Information
- Other Title
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- VIP-Lipopeptide修飾リポソームによる新規ドラッグデリバリーシステム
- VIP-Lipopeptide シュウショク リポソーム ニ ヨル シンキ ドラッグデリバリー システム
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Abstract
We have designed a novel lipid analog (lipopeptide) that mimics the structural features of modified phospholipids. This lipopeptide is easily synthesized using a peptide synthesizer and has been shown to be useful for the modification of liposomes, which are used as an active targeted drug delivery system (DDS). Vasoactive intestinal peptide (VIP) has high homology with pituitary adenylate cyclase activating peptide (PACAP). There are three major PACAP receptors: PAC1R, VPAC1R, and VPAC2R. PAC1R has affinity only for PACAP, whereas VPAC1R and VPAC2R have the same affinity for both VIP and PACAP. In the present study, we synthesized several lipopeptides conjugated with VIP through different linkers and found that liposomes modified with these lipopeptides (VIP-Lips) selectively recognized the PACAP/VIP receptors. The anti-cancer activity of these VIP-Lips was evaluated by encapsulation of an antitumor drug, doxorubicin (DOX), into the modified liposomes (VIP-Lips-DOX) against the human osteosarcoma cell line, Saos-2, which highly expresses the VIP receptor. cAMP production was then measured to determine how well the VIP-Lips were able to recognize VPAC2R. The results clearly indicate that the proposed lipopeptide methodology holds promise as a DDS for cancer therapy.<br>
Journal
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- YAKUGAKU ZASSHI
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YAKUGAKU ZASSHI 134 (9), 987-995, 2014-09-01
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390282681105717376
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- NII Article ID
- 130004684820
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- NII Book ID
- AN00284903
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- COI
- 1:STN:280:DC%2BC2M%2FmvFSrsw%3D%3D
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- ISSN
- 13475231
- 00316903
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- NDL BIB ID
- 025782297
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- PubMed
- 25174370
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed