Salicylanilide誘導体の合成とその抗菌性について

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書誌事項

タイトル別名
  • On the Antimicrobial Activity and Syntheses of Salicylanilide Derivatives
  • Salicylanilide ユウドウタイ ノ ゴウセイ ト ソノ コウキンセ

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抄録

α-(or β-) Naphthol, and p-substituted phenols (or thiophenol) were condensed to 4-chloro-3-nitrobenzotrifluoride or 5-bromo-2-chloronitrobenzene to form their nitro compounds (1-6). Nitro compounds 1-6 were reduced with stannous chloride and hydrochloric acid to the corresponding amino compounds (7-12). Amino compounds (7-12 and 13-16, 23-28, 39-41) were condensed with 5-chloro- and 3, 5-dichloro salicylic acid using phosphorus trichloride in xylene to form their salicylanilide (17-22, 29-38a, 38b, 42-46). Aniline derivatives (47-49) were condensed with salicylaldehyde to form their Schiff bases (50-55). Salicylanilides (17, 20, 29, 31, 34) were acetylated with acetic anhydride and pyridine to form acetylated compounds (56-60). Antimicrobial tests of the synthesized compounds showed that salicylanilides had a strong antimicrobial activity against some gram-positive bacteria.

収録刊行物

  • 薬学雑誌

    薬学雑誌 101 (7), 633-641, 1981

    公益社団法人 日本薬学会

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