書誌事項
- タイトル別名
-
- Dimethylamine Adducts of Barbiturates and Related Compounds and Their Application to Particle Size Reduction
- バルビツールサン ユウドウタイ ソノ カンレン カゴウブツ ト ジメチルアミン
この論文をさがす
抄録
Adduct formation with dimethylamine was confirmed in 5 barbiturates (barbituric acid, mephobarbital, metharbital, phenobarbital, and propallylonal) and phenytoin. The thermal, physico-chemical, and micromeritical properties of these adducts were investigated by differential scanning calorimetry, thermogravimetry, thermomicroscopy, infrared spectroscopy, X-ray powder diffractometry, electron microscopy, and BET gas adsorption analysis. From thermogravimetry, the combining ratios of adducts (barbiturates or phenytoin : dimethylamine) were determined to be 1 : 1 for barbituric acid, mephobarbital, propallylonal, and phenytoin, and 1 : 2 for phenobarbital. As the new absorption band arising from NH2+ stretching vibration appeared in infrared spectra of almost all the adducts, it was strongly suggested that the bonding of an ionic nature would participate in the adduct formation. By desorption of dimethylamine from dimethylamine adducts under reduced pressure with or without heat application, effectively micronized original chemicals were recovered. Their specific surface areas were 2 to 3 times larger in comparison with the corresponding barbiturates recovered via ammonia adducts. The difference in effectiveness in particle size reduction would be attributable to the difference in molecular volume of dimethylamine from ammonia.
収録刊行物
-
- 薬学雑誌
-
薬学雑誌 102 (12), 1150-1161, 1982
公益社団法人 日本薬学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282681105829376
-
- NII論文ID
- 110003650278
- 130007275000
-
- NII書誌ID
- AN00284903
-
- ISSN
- 13475231
- 00316903
-
- NDL書誌ID
- 2620348
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可