数種抗てんかん薬の分離定量法と多剤併用患者への応用

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タイトル別名
  • Simultaneous Determination of Several Antiepileptic Drugs and Its Clinical Application to Some Cases of Multiple-Drug Administration
  • スウシュ コウ テンカンヤク ノ ブンリ テイリョウホウ ト タザイ ヘイヨウ

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説明

The simplified method for the determination of phenytoin (DPH), phenobarbital (PHB), carbamazepine (CBZ), primidone (PRM), valproic acid (VPA), and ethosuximide (ES) was established. In this method, the serum containing these drugs was acidified and extracted with chloroform containing hexobarbital and cyclohexanecarboxylic acid as internal standards. Then, some aliqout of the extract was evaporated to dryness in vacuo, and DPH, PHB, CBZ, and PRM were simultaneously determined by a high-performance liquid chromatography. While, isoamylacetate was added to the other aliqout of the extract, and chloroform was evaporated in vacuo, then VPA and ES were simultaneously determined by a gas-liquid chromatography. These relatively simple procedures gave enough accuracy to determine the serum levels of these drugs in epileptic patients with multipledrug administration. Some cases of the antiepileptic medication were also described in this report. In an epileptic patient, the ratio of cerebrospinal/serum levels of PHB was increased by coadministration of acetazolamide.

収録刊行物

  • 薬学雑誌

    薬学雑誌 102 (11), 1067-1073, 1982

    公益社団法人 日本薬学会

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