書誌事項
- タイトル別名
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- Synthetic Studies of Imidazole C-Nucleosides toward Biofunctional Molecules
- セイタイ キノウセイ ブンシ オ モクテキ ト シタ イミダゾール C ヌクレオシド ノ ゴウセイ ケンキュウ
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Synthetic studies of C4-linked imidazole C-nucleosides toward biofunctional molecules are described, in which the following items are covered. 1) Stereoselective synthesis of imidazole C- and pyrazole C-nucleosides via diazafulvene intermediates. 2) Synthesis of tetrahydrofuranylimidazoles using a PhSe group efficiently and its application to the new human histamine H3 receptor (hH3R) agonist, imifuramine, and the first selective human histamine H4 receptor (hH4R) agonist, OUP-16. 3) Synthesis of imidazole ribonucleoside phosphoramidite (Imz-PA) with pivaloyloxymethyl (POM) group for probing the catalytic mechanism of ribozymes. 4) Synthesis of a two-carbon-elongated homologue (Imz-C2-PA) with a combination of POM and 2-cyanoethyl groups. 5) Incorporation of C2-imidazole nucleoside into position 638 of VS ribozyme using Imz-C2-PA and catalytic activities of the thereby generated modified VS ribozyme (G638C2Imz).<br>
収録刊行物
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- 薬学雑誌
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薬学雑誌 130 (12), 1707-1724, 2010-12-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282681105871488
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- NII論文ID
- 130000451731
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 10921410
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可