中国製ダイエット用健康食品中の<i>N</i>-nitrosofenfluramine の光学純度の決定

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タイトル別名
  • Determination of the Optical Purity of <i>N</i>-nitrosofenfluramine Found in the Chinese Slimming Diet
  • 中国製ダイエット用健康食品中のN-nitrosofenfluramineの光学純度の決定
  • チュウゴクセイ ダイエットヨウ ケンコウ ショクヒン チュウ ノ N nitrosofenfluramine ノ コウガク ジュンド ノ ケッテイ

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From 2001 to the summer of 2002, more than 800 cases of liver damage were reported in Japan among people taking Chinese diet aids. The Japanese Ministry of Health, Labor and Welfare has recently announced that N-nitrosofenfluramine was the hepatotoxic compound contained in the diet aids based on animal experiments performed by the National Institute of Health Sciences. Although N-nitrosofenfluramine is a derivative of fenfluramine, a previously used antiobesity drug, neither pharmacologic nor toxicologic properties have been reported for N-nitroso fenfluramine.<br> It should be noted that N-nitrosofenfluramine has two optical isomers, although it is not yet known which isomer damages the liver and other organs. The Japanese Ministry of Health, Labor and Welfare has not commented on this point. Pursuing this question, 10 types of Chinese slimming aid samples including those obtained from patients with fulminating hepatitis were analyzed by NMR, GC/MS, and a newly established HPLC method using a chiral separation column. It was found that the N-nitrosofenfluramine in all of the toxic diet aids was the (S)-isomer form. No (R)-isomer was detected. These results strongly suggest that the nitroso-compound in the diets must be prepared from pharmacologically active (S)-fenfluramine (dexfenfluramine). Thus the pharmacologic and toxicologic properties of each isomer should be investigated.<br>

収録刊行物

  • 薬学雑誌

    薬学雑誌 123 (9), 805-809, 2003-09-01

    公益社団法人 日本薬学会

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