生薬の生物活性成分に関する研究ケイガイの鎮痛および抗炎症作用

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タイトル別名
  • Biologically Active Principles of Crude Drugs Analgesic and Anti-inflammatory Effects of "Keigai (Shizonepeta tenuifolia BRIQ)"
  • ショウヤク ノ セイブツ カッセイ セイブン ニカンスルケンキュウ ケイガイ

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説明

Screening tests for the analgesic and anti-inflammatory effects of some crude drugs containing volatile oils were carried out by the Whittle method. The results showed that the essential oil fraction of "Keigai (Shizonepeta tenuifolia BRIQ)" inhibited strongly both writhing and capillary permeability in mice. The essential oil of "Keigai" was found to consist mainly of d-menthone (42.9%) and l-pulegone (33.9%). Chemical separation of the essential oil fraction was carried out to clarify the active principles. The analgesic activity was found in d-menthone, and an anti-inflammatory effect was observed in l-pulegone.

収録刊行物

  • 薬学雑誌

    薬学雑誌 100 (7), 713-717, 1980

    公益社団法人 日本薬学会

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