ミトコンドリア標的型Drug Delivery System (DDS) が拓くミトコンドリア創薬への道

DOI Web Site Web Site PubMed 被引用文献2件 参考文献14件
  • 山田 勇磨
    北海道大学大学院薬学研究院薬剤分子設計学研究室
  • 原島 秀吉
    北海道大学大学院薬学研究院薬剤分子設計学研究室

書誌事項

タイトル別名
  • Targeting Mitochondria: Innovation from Mitochondrial Drug Delivery System (DDS) to Mitochondrial Medicine
  • ミトコンドリア ヒョウテキガタ Drug Delivery System(DDS)ガ ヒラク ミトコンドリアソウヤク エ ノ ミチ

この論文をさがす

説明

  Mitochondrial dysfunction has been implicated in a variety of human diseases, including cancer and neurodegenerative disorders. Effective medical therapies for such diseases will ultimately require the targeted delivery of therapeutic agents to mitochondria. This will likely be achieved through innovations in the areas of the nanotechnology of intracellular trafficking. Mitochondrial delivery systems for a variety of cargoes have been repored to date. However, only a limited number of approaches are available for delivering macromolecules directly to mitochondria. We previously reported on the construction of a MITO-Porter, a liposome-based carrier that introduces macromolecular cargos into mitochondria via membrane fusion. Using the green fluorescence protein as a model macromolecule in conjunction with analysis by confocal laser scanning microscopy, we were able to confirm the mitochondrial delivery of a macromolecule by the MITO-Porter. Moreover, we reported that the Dual Function MITO-Porter (DF-MITO-Porter) could efficiently deliver cargo to mitochondria, through endosomal and mitochondrial membranes via step-wise membrane fusion. Here, We will present our findings on the development of our mitochondrial drug delivery system, and discuss our attempts regarding mitochondrial gene delivery and therapy. Finally, We will discuss the potential use of mitochondrial drug delivery systems in mitochondrial medicine.<br>

収録刊行物

  • 薬学雑誌

    薬学雑誌 132 (10), 1111-1118, 2012-10-01

    公益社団法人 日本薬学会

被引用文献 (2)*注記

もっと見る

参考文献 (14)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ