薬物の消化管吸収におよぼすマルチトールおよびマンニトールの影響

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タイトル別名
  • Effects of Maltitol or Mannitol on Gastrointestinal Absorption of Drugs
  • ヤクブツ ノ ショウカカン キュウシュウ ニ オヨボス マルチトール オヨビ

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抄録

Effects of maltitol and mannitol on the gastrointestinal absorption of acetaminophen, sulfisoxazole and riboflavine in mice were investigated. When drugs were orally administered with maltitol or mannitol, and 2 hr after maltitol or mannitol was orally given in mice (in diarrhea), the blood levels of drugs became lower than that in the control, and drug absorption was inhibited. It was suggested that these results were not caused by molecular interaction between drugs and sugar alcohols, but by the action of maltitol and mannitol which accelerated small intestinal motility, secretion and vascular permeability in the intestinal membrane. These changes may be mediated by biogenic amine, serotonin, histamine and polyamines in the small intestine.

収録刊行物

  • 薬学雑誌

    薬学雑誌 100 (11), 1118-1126, 1980

    公益社団法人 日本薬学会

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