Reverse-phase HPLC Determination and Pharmacokinetic Study of Vanillic Acid in the Plasma of Rats Treated with the Traditional Chinese Medicinal Preparation Di-Gu-Pi Decoction

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  A sensitive, simple, and accurate method for the determination and pharmacokinetic study of vanillic acid in rat plasma was developed using reverse-phase HPLC with UV detection after oral administration of the traditional Chinese medicine preparation of the Di-Gu-Pi decoction. Plasma samples taken from rats were extracted with methanol. The constituent vanillic acid was separated on a C18 stationary phase and a mobile phase of acetonitrile-water (15:85, v/v) (adjusted to pH 3.0 using phosphoric acid), with a UV detector setting at 260 nm. The validated HPLC method developed was used to determine the pharmacokinetic profile of vanillic acid in rat plasma after administration of the Di-Gu-Pi decoction.<br>

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  • 薬学雑誌

    薬学雑誌 124 (7), 465-468, 2004-07-01

    公益社団法人 日本薬学会

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