The Effect of Physical Condition in First Emulsification for Yield of Microcapsules

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  • マイクロカプセルの収率に対する一次乳化における物理的条件の効果
  • マイクロカプセル ノ シュウリツ ニ タイスル イチジ ニュウカ ニ オケル

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Description

Ethyl cellulose microcapsules containing aqueous gelatin solution were prepared by the microencapsulation by a multiple (WI/O/WII) emulsion method. Some physical and dynamical factors that affect the formation of emulsion were examined and discussed in the first emulsification. Furthermore, the size, distribution and yield percentage of microcapsules were calculated. The mean length diameter of emulsion (WI/O) was clearly influenced by the viscosity ratio of the internal phase (μi) to the external phase (μe), and then it showed the minimum value at a characteristic viscosity ratio, μi/μe' near to 1.0. In the first emulsification stage, high yield of microcapsules were obtained in the following conditions : 1) Sufficient amounts of sodium sulfate to inhibit coacervation were added in an aqueous solution of gelatin. 2) The mixed solution was mechanically emulsified with a chemistirrer at the high revolution number as possible.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 100 (12), 1203-1208, 1980

    The Pharmaceutical Society of Japan

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