Novel two-step release system for the tradilional Chinese medicine compound Danshen
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- LI Yuanbo
- 3rd Section No. 17, Renmin Nan Road West China Pharmacy School, Sichuan University
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- HOU Shixiang
- 3rd Section No. 17, Renmin Nan Road West China Pharmacy School, Sichuan University
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- BI Yueqi
- 3rd Section No. 17, Renmin Nan Road West China Pharmacy School, Sichuan University
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- ZHENG Yu
- 3rd Section No. 17, Renmin Nan Road West China Pharmacy School, Sichuan University
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- CAI Zheng
- 3rd Section No. 17, Renmin Nan Road West China Pharmacy School, Sichuan University
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- CHENG Qiuhong
- 3rd Section No. 17, Renmin Nan Road West China Pharmacy School, Sichuan University
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- SONG Xiangrong
- 3rd Section No. 17, Renmin Nan Road West China Pharmacy School, Sichuan University
書誌事項
- タイトル別名
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- Novel Two-Step Release System for the Traditional Chinese Medicine Compound Danshen
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A novel two-step release system for the traditional Chinese medicine compound Danshen was developed by combining an effervescent osmotic pump tablet (EOPT) and a pulsed-released tablet (PT) of compound Danshen into one hard capsule. The EOPT of Danshen was prepared with sodium chloride, mannitol, hydroxypropylmethylcellulose (HPMC), and sodium bicarbonate as osmotic agents. The osmotic pressure from EOPT was greatly enhanced by carbon dioxide generated from the reaction between sodium bicarbonate and acidic components from Danshen. It was shown that the tested Danshen components could be completely released from the prepared EOPT following a zero-order release for up to 12 h. The PT of compound Danshen was a three-layer coated tablet composed of organic acid and osmotic agents. Eudragit RL, HPMC and the mixture of EC and Eudragit RS, RL were the major constituents of the separation layer, swelling layer and controlling release membrane, respectively. The swelling test of the PT indicated that swelling is a prerequisite for drug release from this PT device. In addition, the swelling behavior further suggested the drug release mechanism of PT involves diffusion, the osmotic pumping effect, and organic acid-induced effect, among which the osmotic pumping effect was the most important. Moreover, there was no significant difference among the five active constituents in their release profiles from the final combined two-step release system of compound Danshen.<br>
収録刊行物
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- 薬学雑誌
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薬学雑誌 127 (9), 1473-1484, 2007-09-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282681106190848
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- NII論文ID
- 110006380730
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 8937626
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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