Effects of Hachimi-jio-gan (Ba-Wei-Di-Huang-Wan) on Intestinal Function in Streptozotocin-induced Diabetic Rats

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  • HIROTANI Yoshihiko
    Laboratory of Clinical Pharmaceutics, Faculty of Pharmacy, Osaka Ohtani University Department of Pharmacy, Osaka University Hospital
  • IKEDA Takuya
    Department of Pharmacy, Osaka University Hospital
  • IKEDA Kenji
    Laboratory of Clinical Pharmaceutics, Faculty of Pharmacy, Osaka Ohtani University Department of Pharmacy, Osaka University Hospital
  • YAMAMOTO Kaoru
    Department of Pharmacy, Osaka University Hospital
  • ONDA Mitsuko
    Clinical Laboratory of Practical Pharmacy, Osaka University of Pharmaceutical Sciences
  • ARAKAWA Yukio
    Department of Pharmacy, Osaka University Hospital Clinical Laboratory of Practical Pharmacy, Osaka University of Pharmaceutical Sciences
  • LI Jun
    Yanaihara Institute Inc.
  • KITAMURA Kazuyuki
    Yanaihara Institute Inc.
  • KUROKAWA Nobuo
    Department of Pharmacy, Osaka University Hospital

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Description

  We examined the effects of Hachimi-jio-gan (HJ) on the small intestinal function in streptozotocin (STZ)-induced diabetic rats. The rats had free access to pellets containing 1% HJ extract powder for 4 weeks after STZ administration. The intestinal disaccharidase (sucrase and maltase) activity was elevated in STZ-treated rats compared with control rats, whereas it was significantly reduced by HJ administration. This suggested that HJ suppresses or delays monosaccharide production in the small intestinal epithelium. In addition, the intestinal mucosal weights and DNA contents that were significantly increased in the STZ-treated rats were restrained to the control level by HJ treatment. Simultaneously, we examined the changes in the plasma levels of glucagon-like peptide 2 (GLP-2), which is a trophic factor specific for the intestine. The plasma GLP-2 levels significantly increased in the STZ-treated rats, whereas HJ decreased the plasma GLP-2 levels. Thus intestinal mucosal weights and DNA contents correlated with plasma GLP-2 levels in diabetes-associated bowel growth. These results suggest that HJ may normalize or suppress the small intestinal disaccharidase activity and the epithelial cell proliferation mediated by GLP-2 in the animal model rats.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 127 (9), 1509-1513, 2007-09-01

    The Pharmaceutical Society of Japan

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