胃癌患者におけるCyclophosphamideの血漿中および組織中濃度

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タイトル別名
  • Plasma and Tissue Concentrations of Cyclophosphamide in Patients with Gastric Cancer
  • イガン カンジャ ニ オケル Cyclophosphamide ノ ケッショウ

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説明

Plasma concentrations of cyclophosphamide (CPM) were studied in patients with gastric cancer before and after total gastrectomy. The plasma concentration-time curve for total CPM declined biexponentially both before and after the operation after intravenous administration of CPM. A decline in plasma levels of α-phase was accelerated by the operation. The β-phase half-life of CPM was not altered in the postsurgical state. Plasma concentration of the active metabolite (AM) was initially higher after the total gastrectomy than that before the operation. These results suggested that pharmacokinetic studies of CPM before and after the operation should be made to improve adjuvant cancer chemotherapy. Concentrations of total CPM and AM in selected tissues were also investigated.

収録刊行物

  • 薬学雑誌

    薬学雑誌 102 (9), 891-894, 1982

    公益社団法人 日本薬学会

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