New tools for drug discovery provided by NMR structural biology

DOI
  • Kato Koichi
    Graduate School of Pharmaceutical Sciences, Nagoya City University Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences Institute for Molecular Science, National Institutes of Natural Sciences
  • Yanaka Saeko
    Graduate School of Pharmaceutical Sciences, Nagoya City University Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences Institute for Molecular Science, National Institutes of Natural Sciences
  • Yagi-Utsumi Maho
    Graduate School of Pharmaceutical Sciences, Nagoya City University Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences Institute for Molecular Science, National Institutes of Natural Sciences

Bibliographic Information

Other Title
  • NMR構造生物学がもたらす新たな創薬研究のツール

Abstract

<p>In structure-based drug discovery, consideration should be given to conformational dynamics of target proteins and ligand molecules. NMR can provide detailed information on conformational dynamics of biomolecules in various spatial and time scales. In particular, paramagnetic effects offer useful probes for NMR detecting global conformational interchanges of biomolecules. This article outlines current research topics in NMR structural biology underscoring these technical advantages and their potential applications to the drug discovery based on inspection of biomolecular dynamics.</p>

Journal

  • MEDCHEM NEWS

    MEDCHEM NEWS 26 (4), 195-200, 2016

    The Pharmaceutical Society of Japan

Related Projects

See more

Keywords

Details 詳細情報について

  • CRID
    1390282681110407296
  • NII Article ID
    130006510944
  • DOI
    10.14894/medchem.26.4_195
  • ISSN
    24328626
    24328618
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
    • KAKEN
  • Abstract License Flag
    Disallowed

Report a problem

Back to top