Preparation of Stable W/O/W Type Multiple Emulsion Containing Water-Soluble Drugs and in Vitro Evaluation of Its Drug-Releasing Properties

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  • 水溶性薬物を包含した安定なW/O/W型複合エマルションの調製とその薬物放出性のin Vitro評価
  • スイヨウセイ ヤクブツ オ ホウガンシタ アンテイ ナ W O Wガタ フクゴ

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Abstract

The stable water-in-oil-in-water (W/O/W) multiple emulsion was prepared by a two-step procedure for emulsification using glyceryl tricaprylate (Panasate-800) as the oil phase. The water-soluble drugs such as cefadroxil, cephradine, 4-aminoantipyrine, and antipyrine were selected and entrapped separately in the inner aqueous phase of W/O/W multiple emulsion. In consideration of parenteral administration, pH 7.4 phosphate buffered saline was used in both inner and outer aqueous phases. Moreover, these multiple emulsions could be significantly stable for a month at room temperature by the addition of hydrophilic polymer like gelatin and of amino acid like lysine to the inner aqueous phase.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 112 (1), 73-80, 1992

    The Pharmaceutical Society of Japan

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