Sodium Borohydride Reduction of 1, 2, 3-Triazine Derivatives

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Other Title
  • 1,2,3-トリアジン誘導体の水素化ホウ素ナトリウムによる還元
  • 1 2 3 トリアジン ユウドウタイ ノ スイソカ ホウソ ナトリ

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Description

The reduction of substituted monocyclic 1, 2, 3-triazines with sodium borohydride in methanol afforded their 2, 5-dihydro derivatives. The reduction of their 2-methyl quaternary salts also gave the 2, 5-dihydro compounds. The reduction of their 1-oxides and 2-oxides yielded their deoxygenated products and 1, 4, 5, 6-tetrahydro compounds, respectively. The same reaction of 1-methyl-2-oxo-triazinium salts afforded their 1, 6-dihydro derivatives whose structures were elucidated by an X-ray crystallographic study.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 105 (12), 1122-1130, 1985

    The Pharmaceutical Society of Japan

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