Researches on Chemotherapeutic Drugs against Viruses. IX

DOI DOI Web Site Web Site Open Access

Bibliographic Information

Other Title
  • Researches on Chemotherapeutic Drugs against Viruses. VI
  • Syntheses and Antiviral Effects of 3-Phenylazo-4-hydroxynaphthalene Sulfonamide and Its Derivatives

Search this article

Description

1) 3-Phenylazo-4-hydroxynaphthalene sulfonamide and its derivatives were synthesized by diazotizing aniline and its ring-substitutes, and coupling the resulting diazonium compounds with 4-hydroxynaphthalene sulfonamide and its N1-substitutes.<br>2) These compounds were examined as to their activities in vitro against the Nakayama strain of Encephalitis japonica.<br>3) Among these compounds, o- and p-[3-(p-methylphenylazo)-4-hydroxynaphthalenesulfonamido]-benzoic acid possessed the effects approximately equal to that of p-(3-phenylao-4-aminonaphthalenesulf onamido)-benzoic acid, which were proved to possess the strongest effects in vitro and in vivo among all known substances active against neurotropic virus

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 72 (10), 1354-1359, 1952

    The Pharmaceutical Society of Japan

Keywords

Details 詳細情報について

Report a problem

Back to top