Studies on the Syntheses of Coumarin Derivatives. IX

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Bibliographic Information

Other Title
  • クマリン誘導体の合成研究 (第9報)
  • クマリン-3-カルボン酸誘導体の生体内変化について
  • On the Metabolic Change of Coumarin-3-carboxylic Acid Derivatives

Description

Ethyl 7-nitrocoumarin-3-carboxylate and ethyl coumarin-3-carboxylate were each injected into a mouse or applied on excised liver and kidney of a mouse and the fluorescent substance found in the urine, liver, and kidneys was examined by paper chromatography. The results shown in Tables I, II, and IV, suggested the in vitro change of these compounds to be as follows:<br>1) Ethyl 7-nitrocoumarin-3-carboxylate is chiefly reduced in the liver and the kidney and hydrolyzed at the same time to 7-aminocoumarin-3-carboxylic acid. A part of it is further acetylated in the liver to the 7-acetylamino derivative, these two substances being excreted in the urine.<br>2) Ethyl coumarin-3-carboxylate undergoes hydrolysis and other changes in the liver and a part of it changes to coumarin-3-carboxylic acid.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 75 (12), 1489-1491, 1955

    The Pharmaceutical Society of Japan

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