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Antiulcer Activity of Extracts and Isolated Compounds from Zedoary (Gajutsu) Cultivated in Yakushima (Japan)
Bibliographic Information
- Other Title
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- 屋久島産ガジュツ抽出物及び単離成分の抗潰瘍作用
- ヤクシマサン ガジュツ チュウシュツブツ オヨビ タンリ セイブン ノ コウ
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Description
Effects of 8 extracts (YK-1 to YK-8) from Zedoary [Curcuma aeruginosa ROXB. (=C.zedoaria non ROSCOE)] (Gajutsu) cultivated in Yakushima (Japan) and 7 isolated compounds from the extracts on experimental gastric ulcerations were studied. Oral and subcutaneous administrations of the extracts significantly inhibited stress ulcer formation in restrained and water-immersed mice. A n-hexane soluble fraction (YK-3) was more effective than a methanol soluble fraction (YK-2) of the original methanol extract (YK-1). Among the isolated compounds from subfractions (YK-4, YK-5, YK-6) of YK-3, furanogermenone and (4S, 5S)-(+)-germacrone 4, 5-epoxide had a potent preventive effect against stress ulceration. Moreover, oral administration of YK-3, YK-4 and YK-8 significantly inhibited formation of both HCl-induced and indomethacin-induced gastric ulcers. In experiments on effect of YK-3 on gastric secretion and motility, neither of both functions was affected by antiulcer doses of YK-3. These data show that some of extracts and isolated compounds produce a potent inhibition of acute experimental gastric ulcers, partly through their cytoprotective action.
Journal
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- YAKUGAKU ZASSHI
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YAKUGAKU ZASSHI 106 (12), 1137-1142, 1986
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282681130667008
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- NII Article ID
- 130007276185
- 110003648581
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- NII Book ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL BIB ID
- 3124485
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- Data Source
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- JaLC
- NDL Search
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- CiNii Articles
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- Abstract License Flag
- Disallowed