Quantitative Analysis and Pharmaco-Toxicity of Cannabinoids in Commercially Available Cannabis Seeds

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  • 市販の大麻種子中のカンナビノイドの定量とその薬毒理作用
  • シハン ノ タイマ シュシ チュウ ノ カンナビノイド ノ テイリョウ ト ソ

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Abstract

△9-Tetrahydrocannabinol (△9-THC), cannabinol, cannabidiol and cannabichromene were detected in commercially available cannabis seeds by silica gel TLC and gas chromatography. These cannabinoids existed in rather high content (0.10-2.02mg/100g of seeds) in the feed for birds, especially bracts (82.3-441mg/100g). When the suspension prepared from the benzene washing solution of cannabis seeds, BenW, was administered at a dose of 3mg/kg corresponding to △9-THC into a mouse, i.v., BenW caused hypothermia, catalepsy, pentobarbital-induced sleep prolongation and suppression of locomotor activity. These pharmacological activities of BenW were significantly higher than those of △9-THC (3mg/kg, i.v.). These results may indicate the necessity to reconsider the present regulations on marihuana.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 118 (9), 408-414, 1998

    The Pharmaceutical Society of Japan

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