A Simultaneous Determination of Honokiol and Magnolol in Kampo Medicines Containing Magnolia Bark by Ion-Pair High-Performance Liquid Chromatography

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  • イオンペアークロマトグラフィーによる厚朴配合漢方エキス製剤中のHonokiol及びMagnololの同時定量
  • イオン ペアー クロマトグラフィー ニ ヨル コウ ボクハイゴウ カンポウ エ

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Description

A simple and precise method was established for the determination of honokiol (I) and magnolol (II) in kampo medicines containing Magnolia Barks using high-performance liquid chromatography with tetra-n-amylammonium bromide (TAA) as an ion-pair reagent. The optimum conditions for extracting both components from these kampo medicines were 15-min reflux with methanol. I and II were eluted within 9 min and 12 min, respectively, without interference from co-existing components using an ODS column and a mixture of water-acetonitrile containing 10 mM TAA as a mobile phase.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 114 (10), 799-802, 1994

    The Pharmaceutical Society of Japan

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