Antitumor Activity of Enterococcus faecalis FK-23 Preparation against Murine Syngeneic Tumors

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Other Title
  • Enterococcus faecalis FK-23株加熱死菌体のマウス同系腫瘍に対する抗腫瘍効果
  • Enterococcus faecalis FK-23 カブ カネツ シキンタ
  • Antitumor activity of Enterococcus faecalis FK‐23 preparation against murine syngeneic tumors

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Description

The antitumor activity of a preparation of heat-killed cells of Enterococcus faecalis, FK-23. Intraperitoneal injection of the preparation prolonged the lifespan of C3H/He N mice which were intraperitoneally inoculated with MM46 mammary carcinoma. Not only intraperitoneal but also oral administration of the FK-23 preparation inhibited the growth of these carcinomas inoculated intradermally. The tumor-bearing mice produced tumor necrosis factor (TNF) in their sera 2 h after intravenous injection of OK432. This TNF level increased after the mice were fed with food supplemented with the FK-23 preparation. Additionally, the FK-23 preparation inhibited the growth of Meth A fibrosarcoma in cyclophosphamide-treated BALB/c mice.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 113 (5), 396-399, 1993

    The Pharmaceutical Society of Japan

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