書誌事項
- タイトル別名
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- Application of the Limulus Amebocyte Lysate Test to Measurement of Endotoxin in Therapeutic Human Plasma Protein Fraction. Comparison with the Rabbit Pyrogen Test
- カネツ ヒト ケッショウ タンパク セイザイ ニ フクマレル エンドトキシン
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抄録
We applied the limulus amebocyte lysate (LAL) test to the detection of bacterial endotoxins in therapeutic human plasma protein fraction (PPF) and compared the LAL-test with the rabbit pyrogen test. Two endotoxin-specific LAL-reagents were used for the colorimetric method and turbidimetric kinetic method. The amounts of added endotoxin to the PPF were correctly estimated by either method. The results of four independent assays for the 53 samples of PPF corresponded well with each other (correlation coefficient : 0.851-0.959, regression coefficient : 0.898-1.151). The amounts of endotoxin in the PPF estimated by the LAL-test significantly correlated with the rise of body temperature in rabbits (correlation coefficient : 0.547-0.642, and 0.911-0.934 for the endotoxin added samples). These results suggest that the LAL-test could be used as an alternative method for the rabbit pyrogen test to PPF.
収録刊行物
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- 薬学雑誌
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薬学雑誌 112 (8), 551-556, 1992
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282681131430784
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- NII論文ID
- 110003649345
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 3789651
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- NDL
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