書誌事項
- タイトル別名
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- Pharmacological Study on Kefir-A Fermented Milk Product in Caucasus.I. On Antitumor Activity (1)
- コーカサス型発酵乳ケフィアの薬理活性研究-1-抗腫瘍活性について-1-
- コーカサスガタ ハッコウニュウ ケフィア ノ ヤクリ カッセイ ケンキュウ 1
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説明
The antitumor activity of kefir (YK-1), a fermented milk product in Caucasus, was investigated. YK-1 at oral doses of 100 or 500 mg/kg inhibited the proliferation of solid tumor of Ehrlich ascites carcinoma transplanted subcutaneously in mice. YK-1 did not show an inhibitory effect on the ear swelling induced contact dermatitis caused by picryl chloride (PC-CD). However, YK-1 inhibited the immunosuppression in Ehrlich carcinoma-bearing mice and with the freezed and dried ascites of the tumor-bearing mice containing immunosuppressive substances (EC-sup) in PC-CD-induced mice. And also, YK-1 activated the immunosuppressive activity of spleen cells of mouse treated with EC-sup. These results suggest that YK-1 may have antitumor activity against Ehrlich carcinoma and activate the immunosuppression with it.
収録刊行物
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- 薬学雑誌
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薬学雑誌 112 (7), 489-495, 1992
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282681131432192
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- NII論文ID
- 110003649339
- 130007277684
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
- http://id.crossref.org/issn/00316903
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- NDL書誌ID
- 3789660
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- PubMed
- 1432599
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