薬物動態と高速ラプラス逆変換(FILT)

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書誌事項

タイトル別名
  • Disposition Analysis by Fast Inverse Laplace Transform (FILT)
  • ヤクブツ ドウタイ ト コウソク ラプラス ギャク ヘンカン FILT

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説明

A curve fitting program, MULTI (FILT), in which an algorithm of fast inverse Laplace transform is incorporated, was introduced into the area of drug disposition. The reliance of MULTI (FILT) was verified by the Monte Carlo simulation based on compartment models. MULTI (FILT) was applied to the analysis of the local dispositions of drugs through the liver, including the construction of new dispersion model, the effect of albumin in perfusate, and the effect of perfusion rate. The elimination in the lung and the enterohepatic circulation were also evaluated using MULTI (FILT) in a simple manner.

収録刊行物

  • 薬学雑誌

    薬学雑誌 112 (8), 503-515, 1992

    公益社団法人 日本薬学会

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