腸球菌製剤FK-23標品経口投与マウスにおける脾細胞のインターフェロン産生能及びherpes simplex virus-1感染抵抗性の増強
書誌事項
- タイトル別名
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- Augmented Ability of Spleen Cells to Produce Interferons and Prevention from Lethal Infection of herpes simplex virus in Mice Orally Treated with Entrococcus faecalis Preparation, FK-23
- チョウキュウキン セイザイ FK-23 ヒョウヒン ケイコウ トウヨ マウス
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説明
Effects of the oral or intraperitoneal administration of an Enterococcus preparation, FK-23, to mice on the interferon (IFN) production by their spleen cells and on the host defense against the infection with herpes simplex virus (HSV)-1 were examined. Spleen cells were obtained from the mice intraperitoneally treated with cyclophosphamide (CY) and subsequently orally administered FK-23 preparation, and then cultured with phytohemagglutinin-P or bacterial lipopolysaccharide in vitro. They produced higher titers IFN than those obtained from control mice which were not treated with the FK-23 preparation. The IFN activity was neutralized mainly by antiIFN-β antibody. Correspondingly, oral (5mg/mouse) or intraperitoneal (1mg/mouse) administration of the FK-23 preparation protected some of the CY-pretreated mice from death by HSV-1 infection.
収録刊行物
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- 薬学雑誌
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薬学雑誌 116 (4), 323-328, 1996
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282681131605120
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- NII論文ID
- 110003649027
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- NII書誌ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL書誌ID
- 3949205
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- データソース種別
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- JaLC
- NDL
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