Granulation Process and End-Point in High Speed Mixer Granulator

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Other Title
  • 高速攪拌型造粒機の造粒過程及び造粒終点
  • 高速撹拌型造粒機の造粒過程及び造粒終点
  • コウソク カクハンガタ ゾウリュウキ ノ ゾウリュウ カテイ オヨビ ゾウリュ

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Description

Granulation processes in high speed mixer granulator were divided into 4 zones to study the granulation mechanism in each zone. This study showed the importance of evaluating the granulation processes from the view of power consumption change and not from the view of granulation time. It was found that the granulation end-point at which a high yield of well-compacted, spherical small grains was obtained, corresponded to the early phase of zone IV during which the power consumption and granule temperature gained stability. Measurement of the granule temperature is, therefore, helpful for determining the granulation end-point. It was further found that the binder content where a high yield of small grains was obtained, resulted in production of well-compacted, spherical small grains. In granulation with a water-ethanol solution as a binder, the grain sphericity tended to become poorer and the small grains coarser as compared with granulation with purified water as a binder.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 107 (5), 377-383, 1987

    The Pharmaceutical Society of Japan

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