陽性変力作用薬の研究(第3報)6-(Substituted 1-oxoalkyl)-2(1H)quinolinone誘導体の合成

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書誌事項

タイトル別名
  • Studies on Positive Inotropic Agents. III. Synthesis of 6-(Substituted 1-oxoalkyl)-2 (1H)-quinolinone Derivatives
  • 陽性変力作用薬の研究-3-6-(Substituted 1-oxoalkyl)-2(1H)-quinolinone誘導体の合成
  • ヨウセイ ヘンリョク サヨウヤク ノ ケンキュウ 3 6- Substitut

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抄録

Many 3, 4-dihydro-6-(substituted 1-oxoalkyl)-2 (1H)-quinolinone derivatives were synthesized and examined for positive inotropic activity on the canine heart. Among them, 3, 4-dihydro-6-[2-(N-methyl-4-methoxybenzylamino) acetyl]-2 (1H)-quinilinone (Va-2), 3, 4-dihydro-6-[2-(N-methyl-4-cyanobenzylamino) acetyl]-2 (1H)-quinolinone (Va-3) and 6-[2-(N-methyl-4-methoxybenzylamino) acetyl]-2 (1H)-quinolinone (XI) were found to have potent positive inotropic activity with little chronotropic effect.

収録刊行物

  • 薬学雑誌

    薬学雑誌 107 (6), 420-428, 1987

    公益社団法人 日本薬学会

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