非ステロイド性抗炎症剤EB-382の抗アレルギー作用

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書誌事項

タイトル別名
  • The Anti-allergic Effects of EB-382, a Non-steroidal Antiinflammatory Agent
  • ヒ ステロイドセイ コウ エンショウザイ EB-382 ノ コウ アレルギー

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抄録

The anti-allergic effects of EB-382, a non-steroidal antiinflammatory agent, were examined on the experimental animal models of allergic reactions. EB-382 showed no inhibition against the heterologous passive cutaneous anaphylaxis reaction in guinea-pigs (type I). EB-382 suppressed significantly the active Arthus reaction in rabbits at doses of 3 and 10 mg/kg, p.o. and the reversed passive Arthus reaction in guinea-pigs at a dose of 3 mg/kg, p.o. (type III), respectively. EB-382 showed no inhibition on the complement fixation reaction of sheep erythrocytes in vitro (type II) and the tuberculin-induced delayed type allergic reaction in guinea-pigs (type IV). It is suggested that EB-382 is a new type of non-steroidal antiinflammatory agent with a precedent pharmacological action, since it shows an inhibitory effect on the experimental model of type III of allergic reaction.

収録刊行物

  • 薬学雑誌

    薬学雑誌 107 (2), 170-174, 1987

    公益社団法人 日本薬学会

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