Protective Effect of Chinese Medicines on Toxic Side Effects of cis-Diamminedichloroplatinum in Mice

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  • 漢方薬によるシスプラチンの副作用軽減
  • カンポウヤク ニ ヨル シスプラチン ノ フクサヨウ ケイゲン

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Abstract

Effect of oral administration of nineteen kinds of the Chinese medicines on the toxic side effect of cis-diamminedichloroplatinum (cisplatin ; cis-DDP) was examined by using ICR mice. Significant depression of the lethal toxicity and the renal toxicity (indicated by an increase in blood urea nitrogen value) of cis-DDP (45 μmol/kg ; s.c.) was observed in the mice treated with Ginseng and Tang-kuei Ten Combination, Coptis and Rhubarb Combination or Licorice Combination. In mice inoculated i.p. with Ehrlich ascites tumor cells, Ginseng and Tang-kuei Ten Combination, Coptis and Rhubarb Combination and Licorice Combination did not reduce the antitumor effect of cis-DDP. Daily consecutive oral administration of Ginseng and Tang-kuei Ten Combination at a dosage of 50 mg/kg/d completely inhibited the lethal toxicity of cis-DDP. This dosage of the medicine (50 mg/kg/d) is similar to that used in clinical treatment of adult patients. However, the effective doses of Coptis and Rhubarb Combination and Licorice Combination to reduce the toxicity of cis-DDP were about six times higher than those for clinical use. These results suggest that Ginseng and Tang-kuei Ten Combination is the most useful supporting drug for prevention of the toxic side effects of cis-DDP.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 107 (7), 511-516, 1987

    The Pharmaceutical Society of Japan

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