芳香族アルデヒドとα-アミノ酸類の反應に関する研究 (第1報)

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書誌事項

タイトル別名
  • Studies on Reactions between Aromatic Aldehydes and α-Amino Acids. I
  • Studies on Reactions between Aromatic Aldehydes and α-Amino Acids. I
  • 赤堀反應に関する新知見に就いて
  • New Facts on Akabori Reaction
公開日
1951
DOI
  • 10.1248/yakushi1947.71.7_648
公開者
公益社団法人 日本薬学会

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説明

As a result of studies on Akabori reaction (A formula), the following facts were found: (1) In the reaction between benzaldehyde and dl-N-methylalanine, dl-ephedrine and dl-φ-ephedrine are obtained irrespective of the use of pyridine. (2) Similarly, two kinds of dl-compounds of 1-(3, 4-methylenedioxyphenyl)-2-methylaminopropane-1-ol are obtained by heating directly piperonal and dl-N-methylalanine. (3) A new reaction (B formula), differing from the Akabori reaction, takes place by heating directly benzaldehyde and dl-alanine by which benzylamine, 1, 2-diphenylethanolamine (2 kinds of dl-compounds), acetaldehyde and carbon dioxide are formed. From above results, it has been assumed that, when the amino radical in the amino acids used is primary, the reaction of B-type occurs, while when it is secondary, the A-type reaction occurs.

収録刊行物

  • 薬学雑誌

    薬学雑誌 71 (7), 648-651, 1951

    公益社団法人 日本薬学会

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