Adverse Drug Interactions between Pyridonecarboxylic Acids and Nonsteroidal Antiinflammatory Drugs : Convulsion after Oral or Intracerebral Administration in Mice

HIRAI Shiro, TANAKA Keiichi, MAKINO Shinji, NARITA Hirokazu

doi:10.1248/yakushi1947.109.2_119

Bibliographic Information

Other Title

ビリドンカルボン酸系抗菌剤及び非ステロイド性抗炎症剤の薬物相互作用 : マウスでの経口及び脳内投与による痙攣誘発
ピリドンカルボン酸系抗菌剤及び非ステロイド性抗炎症剤の薬物相互作用--マウスでの経口及び脳内投与による痙攣誘発
ピリドンカルボンサンケイコウキンザイオヨビヒステロイドセイコウエン

Search this article

Abstract

Comparing with other pyridonecarboxylic acids (PCAs), the neurotoxicity of (±) -7- (3-amino-1-pyrrolidinyl) -6-fluoro-1- (2, 4-difluorophenyl) -1, 4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid p-toluenesulfonate hydrate (T-3262), which is a new PCA, was investigated in mice in a combination with fenbufen (FBF). T-3262, ofloxacin (OFLX) and nalidixic acid (NA) did not produce convulsion, but enoxacin (ENX) and norfloxacin (NFLX) produced it after an oral administration with FBF. The intracerebral injection of drugs alone to mice revealed that both FBF and 4-biphenylacetic acid (BPAA), which is principally responsible for FBF's antiinflammatory action, scarcely had convulsant activity. While all the PCAs had convulsant activity and the order of potency was as follows ; NFLX > ENX > OFLX > penicillin G potassium > the free base of T-3262 (T-3262 base) &lnE; NA. When orally pretreated with BPAA, the convulsive threshold was scarcely lowered for T-3262 base and OFLX, but for ENX and NFLX it was lowered to about 1/300 and 1/100 of the respective activity. As the result, convulsant activities of ENX and NFLX were greatly potentiated, and their potencies became almost equal. The adverse drug interactions between T-3262 and FBF were scarcely observed in mice.

Journal

YAKUGAKU ZASSHI

YAKUGAKU ZASSHI 109 (2), 119-126, 1989

The Pharmaceutical Society of Japan

Keywords

Details 詳細情報について

Export