書誌事項
- タイトル別名
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- Studies on the Determination and Degradation of Homosulfanilamide. VI
- 消化器管ならびに肝臓におけるホモスルファミンの分解
- Degradation of Homosulfanilamide in the Gastrointestinal Tract and the Liver
この論文をさがす
説明
Homosulfanilamide was found to be decomposed in the body and, in order to examine the location of this decomposition, mode of its decomposition in the digestive tract and various organs was examined.<br>Decomposition in the digestive tract was examined by the use of simulated gastric juice, intestinal juice, and enteric bacteria (Escherichia coli communior, Streptococcus faecalis R, and Lactobacillus acidophilus) but there was no evidence of decomposition and a marked decomposition was found to be effected by intestinal mucosa enzyme.<br>Further examination using the homogenate of rabbit liver and by the perfusion test with excised rabbit liver showed a marked decomposition to take place in both cases. Decomposition of homosulfanilamide on addition of β-phenylisopropylhydrazine or isonicotinic acid hydrazide was examined and it was found that the decomposition of homosulfanilamide was only 30-40% on addition while that of homosulfanilamide was 70% after about 5hours. However, in the test with intestinal mucosa enzyme, effect of these inhibitors was not observed.
収録刊行物
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- 薬学雑誌
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薬学雑誌 82 (12), 1588-1591, 1962
公益社団法人 日本薬学会