Analyses of Drugs and Chemicals by Infrared Absorption Spectroscopy. VIII : Determination of Allylisopropylacetureide and Phenacetin in Pharmaceutical Preparations by Near Infrared Absorption Spectroscopy

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  • 赤外線吸収スペクトルによる医薬品の分析研究(第8報) : 近赤外領域を用いる製剤中のアリルイソプロピルアセトウレイドおよびフェナセチンの定量

Abstract

A near-infrared spectrophotometric method was developed for the determination of allylisopropylacetureide and phenacetin in their pharmaceutical preparations containing allylisopropylacetureide, phenacetin, aminopyrin, isopropylantipyrine, and caffeine, which are difficult to determine at usual NaCl infrared region. Chloroform is chosen as solvent and the sample solution is placed in a quartz cell of 10 mm. light path. The key bands used for allylisopropylacetureide and phenacetin are 5042 and 4952 cm-1, respectively, and these components can be determined easily without interferences of aminopyrine. isopro-pylantipyrine, and caffeine. This method gave good results both in standard mixed samples and unknown samples, and the method is very useful for a routine analysis with simple operations.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 87 (3), 213-215, 1967

    The Pharmaceutical Society of Japan

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