Studies on Pharmaceutical Preparations of Orotic Acid. II

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  • Nakatani Hiromi
    Technical and Process Developing Division, Takeda Chemical Industries, Ltd.

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Other Title
  • オロチン酸の製剤学的研究 (第2報)
  • オロチン酸-アミン反応体の単離と反応体の水に対する溶解性
  • Isolation of Reaction Products of Orotic Acid and Amines, and their Solubility in Water

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Description

Water soluble products were isolated as crystals, when orotic acid and equimolar monoamine were reacted in the concentrated water solution. All of 16 sorts of the product obtained were colorless prisms and the analytical values were coincided with the theoretical ones calculated as the binding ratio of orotic acid to amine to be 1:1. When either nicotinamide or ammonia was reacted with orotic acid by the same method, a similar product was obtained in the ratio of 1:1. The products were very soluble in water and the solubilities were varied with the kind of amine and the structure. There is an interrelative correlation between the solubility and the melting point, that is, the product having lower melting point possesses a larger solubility.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 83 (1), 6-9, 1963

    The Pharmaceutical Society of Japan

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