モルヒネ誘導体の薬理学的研究 (第1報)

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書誌事項

タイトル別名
  • Pharmacological Studies on Morphine Derivatives. I
  • 数種のノルモルヒネおよび14-ヒドロキシノルモルヒノン誘導体の薬理作用
  • Pharmacological Actions of Several Normorphines and 14-Hydroxynormorphinones

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説明

The compounds having morphine rings on both ends of 2-butyne, 1, 4-bis(normorphino)-2-butyne dimethiodide (I), 1, 4-bis(norcodeino)-2-butyne dimethiodide (II), and 1, 4-bis(14-hydroxydihydronorcodeinono)-2-butyne dihydrochloride (III), did not show strong analgesic action or antagonism against morphine. Of these three compounds, III showed anti-barium action close to that of papaverine. Both N-allyl and N-propargyl compounds showed antagonism against morphine and this action was stronger in the former. Antagonism against morphine was seen in any of the actions such as analgesism, suppression of avoidance reactions, hypotension, respiration inhibition, and slowing of brain wave. Toxicity was the weakest in N-propargyl compound. The antagonistic action of N-propargyl-14-dihydroxydihydronormorphinone (RAM-302) against morphine was comparable to that of nalorphine and its toxicity was lower. This antagonistic action against morphine was the same as in the case of analgesic action and the 3-hydroxy compound had stronger action than the 3-methoxy compound.

収録刊行物

  • 薬学雑誌

    薬学雑誌 84 (3), 255-267, 1964

    公益社団法人 日本薬学会

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