Bulbocapnineの合成

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書誌事項

タイトル別名
  • Synthesis of Bulbocapnine
  • Bulbocapnine ノ ゴウセイ

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抄録

The racemic compound of bulbocapnine (I), the tertiary phenolic base of aporphine type obtained from Corydalis tuberosa DC. (Papaveraceae), was synthesized by the route shown in Chart 1. This dl-bulbocapnine (I), m.p. 213-214°, was derived to l-bulbocapnine d-tartrate by the application of d-tartaric acid, and l-bulbocapnine (Ib), m.p. 202-203°, was obtained in pure state from this d-tartrate. The application of l-tartaric acid to dl-bulbocapnine (I) gave d-bulbocapnine l-tartrate, from which pure d-bulbocapnine (Ia), m.p. 201-203°, was obtained.<br>Application of methyl iodide to d- and l-bulbocapnines so obtained afforded the quaternary phenolic base of aporphine type, d- and l-bulbocapnine methiodides (XIa and XIb), m.p. 253-254° (decomp.), and the methiodides were converted by silver chloride into respective methochlorides (XIIa and XIIb), m.p. 226-228° (decomp.).

収録刊行物

  • 薬学雑誌

    薬学雑誌 79 (10), 1244-1248, 1959

    公益社団法人 日本薬学会

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