Studies on the Synthesis of Quinoline Compounds. VIII

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Other Title
  • キノリン系化合物の合成研究 (第8報)
  • 4-クロロキナルジン系化合物とサリチルアミドの縮合反応
  • Condensation Reaction of 4-Chloroquinaldine Compounds and Salicylamide

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Description

It was discovered that salicylamide can be used as an amination agent. Condensation of salicylamide with 4-chloroquinaldine compounds results in the formation of compounds of N-(2-methyl-4-quinolyl)salicylamide and 4-aminoquinaldine types, differing from the case of m- and p-hydroxybenzamides, the hydroxyl being stabilized by intramolecular chelation and the acid amide acting like an amine. On the other hand, condensation of m- and p-hydroxybenzamide with 4-chloroquinaldine compounds results in hydroxyl substitution and compound of 4-(carbamoylphenoxy)quinaldine type is formed.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 81 (3), 352-358, 1961

    The Pharmaceutical Society of Japan

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