抗結核剤の試験管内作用に対する金属イオンの影響と錯塩形成との関連 (第3報)

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書誌事項

タイトル別名
  • Influence of Metal Ions on the <i>in vitro</i> Activity of Antituberculosis Agents and its Relation to Metal Complex Formation. III
  • 抗結核剤に対し金属イオンが影響を及ぼす機作に関する1仮説
  • A Hypothesis for the Mechanism of the Effect of Metal Ions on the Activity of Antituberculosis Agents

抄録

It was found that the effect of Ca, Cu, Ni, Fe (III), Al, Hg, Mg, Zn, Mn, Cd, and Co (II) on the in vitro action of PAS, INAH, TBI, SM, and DHSM against sensitive and resistant strains of human-type tubercle bacilli and the presence or absence of tendency of these metallic ions to form a complex with these antitubercular agents were in parallel relation. This suggests the role of complex formation in the mechanism of these metals affecting the in vitro action of antitubercular agents. As was pointed out earlier, the effect of metals cannot be explained by the direct action of the metal on tubercle bacilli or the toxic action of the metal complex itself. In this connection, a hypothesis has been presented on the effect of metals on the in vitro action of these antitubercular agents. The antitubercular action of these agents seems to be displayed in connection with a requisite metal in an enzyme. When a metal forms a complex salt with a substance which competes with the antitubercular agent for this particular metal, a synergism between a metal and the agent occurs, but when the antitubercular agent and the said metal forms a complex salt, then antagonism occurs. Which complex is formed depends on the stability of the complex. This hypothesis can well explain the facts observed and reported in Parts I and II of this series.

収録刊行物

  • 薬学雑誌

    薬学雑誌 76 (7), 839-842, 1956

    公益社団法人 日本薬学会

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