メチルビリジン誘導体の合成(第25報) : α-置換-2-pyridineacetonitrile誘導体の合成

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タイトル別名
  • Synthesis of Methylpyridine Derivatives. XXV. : Synthesis of α-Substituted 2-Pyridineacetonitriles
  • Synthesis of Methylpyridine Derivatives. XXV. : Synthesis of α-Substituted 2-Pyridineacetonitriles

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説明

Reaction of 2-pyridineacetonitrile (II) with aldehydes in the presence of sodium hydroxide or piperidine in ethanol gives α-alkylidene-2-pyridineacetonitrile (V). II does not react with ketones under the same condition but does react with benzophenone in the presence of sodium amide to give α, α-diphenyl-2-pyridineethanol (IX). II easily transits to α-acyl-2-pyridineacetonitrile (X) by reaction with acid halides. Catalytic reduction, hydrolysis, and Grignard reaction of V are also described.

収録刊行物

  • 薬学雑誌

    薬学雑誌 89 (2), 188-193, 1969

    公益社団法人 日本薬学会

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