Bibliographic Information
- Other Title
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- 6-Hydroxycortisol 6-Hemisuccinateの合成
- 6 Hydroxycortisol 6 Hemisuccinate ノ ゴウセ
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Abstract
The selective acetylation of 17α, 20, 20, 21-BMD-pregnan-5α, 6β, 11β-triol-3-one (IV), derived from cortisone, was led to its 6β-acetate (V). A solution of V in CHCl3 containing EtOH (0.7%) was treated with HCI gas to give 17α, 20, 20, 21-BMD-4-pregnene-6α, 11β-diol-3-one-6-acetate (VIa) and in pure CHCl3 to give 6β-derivative (VIb). The hydrolysis of 6-O-acetate of VIa with K2CO3 followed by succinylation with succinic anhydride gave 17α, 20, 20, 21-BMD-4-pregnene-6α, 11β-diol-3-one 6-hemisuccinate (VIIIa). 6α-Hydroxy- cortisol 6-hemisuccinate (IXa) was obtained by the hydrolysis of the bismethylenedioxy protecting group in VIIIa with 50% AcOH. 6β-Hydroxycortisol 6-hemisuccinate (IXb) was also obtained from VIb by the same procedure.
Journal
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- YAKUGAKU ZASSHI
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YAKUGAKU ZASSHI 95 (2), 185-189, 1975
The Pharmaceutical Society of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390282681191695744
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- NII Article ID
- 110003652029
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- NII Book ID
- AN00284903
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- ISSN
- 13475231
- 00316903
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- NDL BIB ID
- 1589011
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed