Simultaneous Determination of Glycyrrhizin and Glycyrrhetic Acid in Plasma by High Speed Liquid Chromatography

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Other Title
  • 高速液体クロマトグラフィーによる血中グリチルリチンおよびグリチルレチン酸の同時定量
  • 高速液体クロマトグラフィーによる血中グリチルリチンおよびグリチルリチン酸の同時定量
  • コウソク エキタイ クロマトグラフィー ニヨル ケッチュウ グリチルリチン オ

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Description

Simultaneous determination of glycyrrhizin (G) and glycyrrhetic acid (GA) in plasma was established by high-speed liquid chromatography. G and GA were extracted from plasma with 0.25 N NH4OH·85% EtOH. The extracted sample containing indomethacin as an internal standard was analysed on a reverse-phase column (SC-02-250) with gradient elution from water to 0.5% acetic acid-90% acetonitrile.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 98 (11), 1545-1547, 1978

    The Pharmaceutical Society of Japan

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