吸収排泄におよぼす医薬品の併用効果(第9報)家兎におけるサルファ剤の血中濃度に及ぼすサリチル酸の影響

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タイトル別名
  • Effect of Simultaneous Administration of Drugs on Absorption and Excretion. IX. Effect of Salicylic Acid on Blood Levels of Sulfonamides in Rabbits
  • 吸収排泄におよぼす医薬品の併用効果-9-家兎におけるサルファ剤の血中濃度に及ぼすサリチル酸の影響
  • キュウシュウ ハイセツ ニ オヨボス イヤクヒン ノ ヘイヨウ コウカ 9 カ

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抄録

The influence of protein binding displacement on sulfonamide blood levels was studied, using salicylic acid as the displacing drug. When five different sulfonamides were orally administered with salicylic acid to rabbits, blood levels of sulfadimethoxine and sulfisoxazole which shown high binding to bovine serum albumin (BSA) markedly decreased, whereas blood levels of sulfanilamide which shows low binding to BSA did not change. In addition, a significant correlation (r=-0.974) was observed between the decrease in sulfonamide blood levels and the increase in unbound sulfonamide concentrations. These results indicate that protein binding displacement is an important determinant affecting the blood levels of highly bound drugs.

収録刊行物

  • 薬学雑誌

    薬学雑誌 98 (12), 1663-1667, 1978

    公益社団法人 日本薬学会

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