A Potential Mechanism for Spontaneous Oscillation in the Abnormal Retina

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  • Taniguchi Kanako
    Graduate School of Information Science and Engineering, Ritsumeikan University
  • Koike Chieko
    Graduate School of Life Sciences, Ritsumeikan University College of Pharmaceutical Sciences, Ritsumeikan University Center for Systems Vision Science, Research Organization of Science and Technology, Ritsumeikan University
  • Kitano Katsunori
    College of Information Science and Engineering, Ritsumeikan University

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Other Title
  • 病変網膜における自発振動活動発生メカニズム
  • Symposium Review 病変網膜における自発振動活動発生メカニズム
  • Symposium Review ビョウヘン モウマク ニ オケル ジハツ シンドウ カツドウ ハッセイ メカニズム

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Abstract

　Rhythmic neural activities are observed in many brain regions, and these are considered to play an important role in neural information processing. On the other hand, distinct rhythmic neural activities emerge under several pathological conditions, suggesting that rhythmic neural activity has a close relation to brain function and dysfunction. In many pathological cases, the intrinsic property of unusual rhythm generation in a neuron or a neuronal network is prevented under normal conditions, but released by the pathological condition. Therefore, it may be useful to explore which conditions determine rhythm generation in order to understand the mechanisms of brain function/dysfunction. The pathological retina in retinal degeneration exhibits rhythmic neural activity not observed in the healthy retina. In this review, we first provide a brief introduction to the possible mechanisms of rhythm generation in a neural system. Then we introduce experimental evidence of rhythm generation in the pathological retina, as well as two hypotheses regarding this mechanism. Finally, we raise several issues to be solved for the further understanding of pathological rhythm generation.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 138 (5), 685-692, 2018-05-01

    The Pharmaceutical Society of Japan

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