Effect of Reserpine Pretreatment on Ear Temperature Decreasing Action of Norepinephrine and Ethylphenylephrine in Rabbits

DOI Web Site Web Site

Bibliographic Information

Other Title
  • Norepinephrine, Ethylphenylephrineのウサギの耳介温度低下作用に対するReserpine前処置の効果
  • Norepinephrine,Ethylphenylephrineのウサギの耳介温度低下作用に対するReserpine前処置の効果(ノート)
  • Norepinephrine Ethylphenylephrine ノ ウサギ

Search this article

Description

Effect of reserpine pretreatment on the lowering of skin temperature, resulting from contraction of peripheral blood vessels by norepinephrine and ethylphenylephrine, was examined by the measurement of ear temperature in uninjured rabbits. Rabbits were injected subcutaneously with 5 mg/kg of reserpine 24 hr before the experiment. Lowering of the ear temperature in rabbits given either of the two drugs was stronger and lasted longer than that in nontreated rabbits. The dose-reaction relation (area below the time-lowering degree curve) shifted towards the left by the two drugs in the treated animals, and the lowering action was 2-fold stronger in norepinephrine and ca. 5-fold stronger in ethylphenylephrine than in nontreated animals. These results indicate that pretreatment with reserpine fortifies the lowering action when sympathomimetic amines (vasoconstrictors) are evaluated with lowering of ear temperature as the index.

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 97 (5), 597-599, 1977

    The Pharmaceutical Society of Japan

Keywords

Details 詳細情報について

Report a problem

Back to top